Many years after the confrontation with Van Helsing, Dracula landed in Whitby, England once again. The citizens of Whitby sought help from the vampire hunter, Professor Van Helsing. Will Van Helsing defeat Dracula before he transforms all the inhabitants into vampires?

In Dracula vs Van Helsing, each player controls one of the title characters. Van Helsing must remove all of Dracula's life points to win, but if Dracula turns all four inhabitants of the same district into vampires first, Dracula wins.